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Dr Agata Starosta

event-date: 06.08.2018
Place: MCB Seminar Room 3/14

Time: 13:00
Title:
 
“Undercover translation Hidden secrets of the ribosomes”
Host: Sebastian Glatt

Abstract

Ribosomes are a center of every living cell. For decades, they were perceived as homogeneous macromolecules carrying a constant set of ribosomal RNAs and proteins. Consequently, they were not considered to actively participate in the regulatory role of gene expression. The hypothesis of specialized ribosomes assumes the existence of a subpopulation of ribosomes carrying unique structural properties allowing fast and precise response to environmental stimuli throughout selectivity for distinct mRNAs. We use sporulation process in Bacillus subtilis as a model to study regulation of gene expression on translational level. Using combination of ribosome profiling, genetics, biochemistry and microscopy, I aim to identify factors modulating translation and accounting for ribosomal selectivity towards mRNAs. Initial data shows massive global rearrangements in proteins synthesis profile and unveils interesting events, like expression of previously unannotated genes, occurrence of paralogues of ribosomal proteins or rearrangements in the ribosomal structure – implying a presence of distinct sub-sets of ribosomes. Finding specialized ribosomes will add a new level of regulation of gene expression with a ribosome as an active element. Moreover, within the result, we may identify critical elements suitable for the rational design of new drugs, leading to discovery of novel potential targets for antimicrobials.
Published Date: 10.07.2018
Published by: Paweł Dudek